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AlzRisk Paper Detail
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Reference: Hughs, 2009
Cohort: Kame Project
Risk Factor: Obesity


Exposure Detail
Method of BMI ascertainment: measurement by trained interviewers

"At the baseline examination, anthropometric measurements including height, weight, WC, and hip circumference were taken by trained interviewers and recorded for each participant. Only weight was measured at each of the follow-up examinations. BMI (weight[kg] over height squared [m2] was considered the primary index of body weight, since it is scaled according to height and was categorized as obese (BMI>=25), overweight (BMI=23.0-24.9), normal (BMI=18.5=22.9), and underweight (BMI <18.5) according to cutoffs proposed by the International Obesity Taskforce for Asian populations."

"Fixed slope parameters for each participant were calculated using random effect modeling and served as a measure of rate of change in BMI across the study period (mean=-0.07, SD=0.11)."

The investigators conducted the analyses adjusting for different sets of covariates. This row corresponds to the analysis performed adjusting for age, gender and education only.

Age Detail
All participants were at least 65 years of age at study entry.

Screening and Diagnosis Detail
Screening Method:
CASICognitive Abilities Screening Instrument (Teng 1994)

AD Diagnosis:
CDR Clinical Dementia Rating (Berg 1988)
CERAD Consortium to Establish a Registry for Alzheimer’s Disease (Morris 1989)
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
Ggender

TD Covariates:
Aage
Eeducation
Ggender