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AlzRisk Paper Detail
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Reference: Fitzpatrick, 2009
Cohort: Cardiovascular Health Cognition Study/Cardiovascular Health Study Cognition Study
Risk Factor: Obesity


Exposure Detail
The authors evaluated associations between midlife BMI (self-reported BMI at age 50) and AD as well as late-life BMI (collected at baseline) and AD. This row of results corresponds to the association between late-life BMI and AD.

We have only provided results of the analyses adjusting for age, race, sex and educational level in these tables, and not those adjusting for potential intermediates such as DM.

Method of BMI ascertainment: technician mesurement

"Anthropometric measurements in late life were collected in person at the clinic visit occurring closest to the time of the CHS MRI. These measurements included height, weight and waist-hip circumference in 1992-1993 (baseline for the CHS-Cognition). Midlife weight, however, relied on self-report of weight at age 50 years collected on the medical history form. Midlife BMI was calculated as weight in kilograms divided by height in meters squared and waist-hip ratio (WHR) as the ratio of waist to hip circumference."

Age Detail
Study entry criteria required participants to be at least 65 years of age.

Screening and Diagnosis Detail
Screening Method:
MMSEMini-Mental State Examination (Folstein 1975)
TICSTelephone Interview of Cognitive Status

AD Diagnosis:
Brain Imaging
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
Ggender
RErace/ethnicity

TD Covariates:
Aage
Eeducation
Ggender
RErace/ethnicity