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AlzRisk Paper Detail
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Reference: Hayden, 2006
Cohort: Cache County Study
Risk Factor: Obesity


Average Follow-up Time Detail
"Briefly, all residents of the county aged 65 or older as of January 1, 1995 were invited to participate...A second evaluation of the cohort took place 3 years later, from 1998 to 1999... Participants' cognitive status was assessed via a multistage screening procedure at follow-up, approximately 3.2 years (range= 2 to 5y, standard deviation = 0.44) after the baseline assessment."

Exposure Detail
Method of ascertaining BMI: self-report or proxy-report

For an indicator of obesity, individual's self-reported or proxy-reported height and weight at baseline were used to calculate body mass index (BMI) (kilogram divided by meters squared). Persons whose BMI was >=30 were recorded as obese.

The authors conducted the analyses for the overall population, and after restricting the study population to men or women. These results correspond to effect estimates obtained for the entire study population.
The analyses were adjusted for age, gender, education, APOE status, and cardiovascular risk factors.

Ethnicity Detail
"...this population is primarily white and is genetically similar to other US populations of Northern European decent."

Age Detail
All participants were 65 years or older at baseline.

Screening and Diagnosis Detail
Screening Method:
DQDementia Questionnaire (Silverman 1986)
IQ-CODEInformant Questionnaire for Cognitive Decline in the Elderly (Jorm 1989)
3MSEModified Mini-Mental State Examination (Teng 1987)

AD Diagnosis:
DSM IIIR Diagnostic and Statistical Manual III-Revised
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total Dementia Definition: Dementia was diagnosed via DSM-III-R criteria using all available information. Severity was additionally assessed using the Clinical Dementia Rating Scale.

Covariates & Analysis Detail
Analysis Type:
Discrete-time survival modeling

These results correspond to the analysis conducted without stratifying by sex.

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
CABGcoronary artery bypass graft
DMdiabetes mellitus
HChigh cholesterol
HTNhypertension
MImycardial infarction history
SHstroke history

TD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
CABGcoronary artery bypass graft
DMdiabetes mellitus
HChigh cholesterol
HTNhypertension
MImycardial infarction history
SHstroke history