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AlzRisk Paper Detail
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Reference: Ravaglia, 2005
Cohort: Conselice Study of Brain Aging
Risk Factor: B Vitamins


Exposure Detail
Baseline venous blood samples were taken after an overnight
fast. Serum samples for vitamin B12 measurements were sent to the biochemical laboratory for immediate immunoelectrochemiluminescence analysis. For vitamin B-12, intra- and interassay CVs were 4.3% and 4.6%, respectively.

Ethnicity Detail
Participants were residents from the Italian municipality of Conselice (province of Ravenna, Emilia Romagna region.

Screening and Diagnosis Detail
Screening Method:
MMSEMini-Mental State Examination (Folstein 1975)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-IV.

"Dementia was defined on the basis of the clinical criteria of the
Diagnostic and Statistical Manual of Mental Disorders, 4th
edition (24). AD was diagnosed on the basis of NINCDS-ADRDA (National Institute of Neurological and Communicative Disease and Stroke–Alzheimer’s Disease and Related Disorders Association) criteria for probable or possible AD [25]. Diagnoses were independently made by 2 physicians (PF and FM) on the basis of all available information. Finally, a diagnostic conference with a third senior physician (RG) was held to discuss each case."

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
HCYplasma homocysteine
CRTserum creatinine
SHstroke history
VTBvitamin B12

TD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
HCYplasma homocysteine
CRTserum creatinine
SHstroke history
VTBvitamin B12