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Non-Steroidal Anti-Inflammatory Drugs
Dietary habits were recorded at baseline using a brief food frequency questionnaire.
Frequent fish consumption was defined as fish or seafood consumption at least once a week. Frequent fruit and vegetable consumption was defined as a consumption at least daily. Consumption of regular n-3 rich oils was defined as any consumption of colza, walnut, or soya oils. A poor dietary pattern was defined as infrequent fish, fruit, vegetable, and no regular n-3 rich oil consumption.
Participants included residents from the cities of Bordeaux, Dijon, and Montpellier, France. No other information on ethnicity was reported.
Screening and Diagnosis Detail
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition
: Dementia via DSM-IV.
"Diagnosis of dementia was based on a three-step procedure.
. Trained psychologists administered a battery of neuropsychological tests. All the participants in Bordeaux and Montpellier were then examined by a neurologist at baseline, whereas in Dijon only those who screened positive underwent further examination because of the many participants. At follow-up, the participants who were suspected of incident dementia on the basis of their neuropsychological performance were examined by a neurologist in the three study centers. Finally, an independent committee of neurologists reviewed all potential prevalent and incident cases of dementia to obtain a consensus on its diagnosis and etiology according to the criteria of theDiagnostic and Statistical Manual of Mental Disorders, fourth edition. Cases of AD were classified as probable or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria."
Covariates & Analysis Detail
Cox proportional hazards regression
Age was the time scale in the proportional hazards analysis.
APOE e4 genotype
APOE e4 genotype