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AlzRisk Paper Detail
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Reference: Barberger-Gateau, 2007
Cohort: Three-City Study
Risk Factor: Dietary Pattern


Exposure Detail
Dietary habits were recorded at baseline using a brief food frequency questionnaire.

Frequent fish consumption was defined as fish or seafood consumption at least once a week. Frequent fruit and vegetable consumption was defined as a consumption at least daily. Consumption of regular n-3 rich oils was defined as any consumption of colza, walnut, or soya oils. A poor dietary pattern was defined as infrequent fish, fruit, vegetable, and no regular n-3 rich oil consumption.

Ethnicity Detail
Participants included residents from the cities of Bordeaux, Dijon, and Montpellier, France. No other information on ethnicity was reported.

Screening and Diagnosis Detail
AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-IV.

"Diagnosis of dementia was based on a three-step procedure.
[12]. Trained psychologists administered a battery of neuropsychological tests. All the participants in Bordeaux and Montpellier were then examined by a neurologist at baseline, whereas in Dijon only those who screened positive underwent further examination because of the many participants. At follow-up, the participants who were suspected of incident dementia on the basis of their neuropsychological performance were examined by a neurologist in the three study centers. Finally, an independent committee of neurologists reviewed all potential prevalent and incident cases of dementia to obtain a consensus on its diagnosis and etiology according to the criteria of theDiagnostic and Statistical Manual of Mental Disorders, fourth edition[16]. Cases of AD were classified as probable or possible AD according to the National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria[1]."

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

Age was the time scale in the proportional hazards analysis.

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
CCcity center
INCIncome
MSmarital status

TD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
CCcity center
INCIncome
MSmarital status