Enter your keywords
HOME
About Us
NEWSLETTER
To search AlzRisk, use the "Keyword" search on the
AlzRisk search page
.
NEWS
All News
Conference Coverage
Series
WEBINARS
All Webinars
Databases
AlzBiomarker
AlzPedia
AlzRisk
Antibodies
Genetics
AlzGene
HEX
Mutations
Protocols
Research Models
Therapeutics
PAPERS
All Papers
Papers of the Week
Milestone
Alzforum Recommends
PROFESSIONAL RESOURCES
Conference Calendar
Grants
Jobs
Member Directory
ABOUT AD
AD Overview
Early-Onset Familial
The HBO Alzheimer's Project
Supported Browsers
MY ALZFORUM
My AlzForum Home
View Library
View Notifications
Set Notifications
Edit Profile
AlzRisk Paper Detail
Risk Factors
Alcohol
B Vitamins
Blood Pressure
Cognitive Activity
Diabetes Mellitus
Dietary Pattern
Head injury
Homocysteine
Hormone Therapy
Inflammatory Biomarkers
Non-Steroidal Anti-Inflammatory Drugs
Nutritional Antioxidants
Obesity
Physical Activity
Statin use
Reference:
Beydoun, 2011
Cohort:
Baltimore Longitudinal Study of Aging
Risk Factor:
Statin use
Average Follow-up Time Detail
The median follow-up time for the original cohort was 24.9 years. The article does not provide the mean follow-up time for participants included in this analysis.
Exposure Detail
The investigators ascertained the exposure information by taking an inventory of all over-the-counter and prescription medication in current use at each visit.
The investigators compared incident AD risk in two groups:
the group of participants who ever used statins beyond 50 years of age and before the onset of dementia or mild cognitive impairment (MCI) ("Ever used") and the reference group of participants who never used statins, or if they used them only at or prior to age 50, or only at or after the onset of dementia or MCI ("Never used").
Screening and Diagnosis Detail
Screening Method:
Blessed
Blessed Information-Memory-Concentration Test
CDR
Clinical Dementia Rating (Berg 1988) (CDR)
DQ
Dementia Questionnaire (Silverman 1986)
AD Diagnosis:
DSM IIIR
Diagnostic and Statistical Manual III-Revised
NINCDS ADRDA
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition:
Dementia via DSM-IIIR
Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression
AD Covariates:
A
age
E
education
G
gender
BMI
body mass index
CVD
cardiovascular disease
DLM
dyslipidemia
HTN
hypertension
RE
race/ethnicity
SM
smoking status
SBP
systolic blood pressure
§ Covariates for total dementia are different.
TD Covariates:
A
age
E
education
G
gender
BMI
body mass index
CVD
cardiovascular disease
DLM
dyslipedemia
HTN
hypertension
RE
race/ethnicity
SM
smoking status
SBP
systolic blood pressure