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PDGene - Meta-Analysis of All Published PD Association Studies (Case-Control Only) rs1564282
Back Search Methods Disclaimer Credits
 Polymorphism: rs1564282
 Gene: GAK  (FLJ16629; FLJ40395; MGC99654; PARK17)  Entrez Gene
 Protein: cyclin G associated kinase   ProteinLink
 Chromosome: 4   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011 ;  ***Note that in addition to GAK, the gene DGKQ in this locus shows genome-wide significant effects in PDGene meta-analyses. As statistical significance is currently weaker than for GAK, DGKQ is not listed in the top results, but can be accessed via the PDGene search function.***
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  T-Allele
(frequency)
C-Allele
(frequency)
T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian 3 PD
CTR
0.11
0.09
0.89
0.91
50 (0.013)
61 (0.008)
803 (0.202)
1211 (0.162)
3125 (0.786)
6195 (0.830)
Total 3 PD
CTR
0.11
0.09
0.89
0.91
50 (0.013)
61 (0.008)
803 (0.202)
1211 (0.162)
3125 (0.786)
6195 (0.830)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs1564282

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

rs1078139
rs1134921
rs11726508
rs17781348
rs17781378
rs2061846
rs2127168
rs2279186
rs2306245
rs3755959
rs3755963
rs3755964
rs3822023
rs6964
rs755447

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Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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