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PDGene - Gene overview of all published PD-association studies for HLA-DRB5
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 Gene: HLA-DRB5  (hCG_1998957; FLJ76359; HLA-DRB)  Entrez Gene
 Protein: major histocompatibility complex, class II, DR beta 5  (DR beta-5; DR-9; DR2-beta-2; DR9; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; MHC class II HLA beta chain; MHC class II antigen DRB1*9; MHC class II antigen DRB5; dw2; human leucocyte antigen DRB5; leukocyte antigen class II)  ProteinLink
 Chromosome: 6   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 28 April 2011
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
# Subjects
(% women)
IPDGC, 2011
France (GWAS) CL,PO  1  (detail)  1039
U48.9 + 48.9
73.7 + 5.4
IPDGC, 2011
Germany (REP-Immuno) CL  1  (detail)  1153
IPDGC, 2011
UK (REP-Immuno) CL  1  (detail)  1271
IPDGC, 2011
USA (PROGENI/GenePD-GWAS) CL  1  (detail)  876
U61.5 + 61.5
IPDGC, 2011
USA (REP-Immuno) CL  1  (detail)  2807
IPDGC, 2011
Netherlands (REP-Immuno) CL  1  (detail)  304
IPDGC, 2011
UK (WTCCC-GWAS) CL,PO  1  (detail)  1705
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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